Stop Pain Cold ... with no opioids

Long Lasting Non-Opioid Cold Knee Therapy Relief

The mechanism of pain can be simplified as follows: sensory nerves transmit pain (sensory) signals from the affected region to the brain.  The brain then instructs that specific (affected) region in the body to alter its function to help mitigate the pain.  The body’s natural response to pain, especially musculoskeletal pain, disrupts physical function.  This pain affects and inhibit one’s normal daily activities.

The iovera°® technology disrupts the transmission of pain signals to the brain by taking advantage of the body’s natural response to cold.  This mechanism is referred to as cryoanalgesia (cryo = cold, analgesia = pain relief)

History of Cryoanalgesia

Cold has been used to relieve pain since the days of Hippocrates in ancient Greece. Modern cold therapy, or cryotherapy, has been around since the 1950s and is a trusted technology for treating pain.  

The History of Cryoanalgesia
History of Cryoanalgesia

Cryoanalgesia (also known as cryoneurolysis) is the reversible destruction of the signal carrying parts of a nerve.  It is a small subset of treatments under the broad umbrella of cryotherapy.

Until now, traditional cryotherapy treatments were invasive, and used large complicated machines.

The ioverao system has revolutionized the delivery of cryoanalgesia.  With the ioverao system, doctors are able to deliver precise, controlled doses of cold temperature only to the targeted nerve through a handheld device.  This needle-based procedure is safe, and does not damage or destroy the surrounding tissue.

How it Works

What is the iovera° treatment?

The ioverao treatment uses the body’s natural response to cold to treat peripheral nerves and immediately reduce pain – without the use of drugs. Treated nerves are temporarily stopped from sending pain signals for a period of time, followed by a restoration of function.

It is important to note that the ioverao therapy does not treat the underlying cause of the pain.  Timely remediation is necessary to address and treat the cause of pain.


How does iovera° treatment work?

The ioverao treatment works by applying targeted cold to a peripheral nerve.  A precise cold zone is formed under the skin – cold enough to immediately prevent the nerve from sending pain signals without causing damage to surrounding structures.  The effect on the nerve is temporary, providing pain relief until the nerve regenerates and function is restored.

The ioverao treatment does not include injection of any substance- drugs, opioids or narcotics.  The effect of this treatment is immediate and can last up to 90 (ninety) days.  In one study, majority of the patients suffering from osteoarthritis of the knee have experienced pain and symptom relief beyond 150 days.1

How does it Compare to Other Modalities

Drugs - NSAIDs and narcotics

Mild analgesics such as aspirin and ibuprofen (Non-Steroidal Anti-Inflammatory Drugs – NSAIDs) and more powerful ones like opioids and narcotics relieve pain but affect the entire body.  

Click here for a list of side effects from these drugs.

A minimum of one dose per day may required for any of these drugs.  Continuous dosage may in turn have effects on other parts of the body.

iovera° treament


The ioverao technology is used to treat specific nerves so the pain relief is focused only on the part of the body that is being treated.

Click here for a complete list of side effects of the iovera treatment.

One treatment with the iovera system can last 90 days.  Majority of patients have continued to experience relief beyond 150 days in clinical trial.1

1Radnovich, R. et al. “Cryoneurolysis to treat the pain and symptoms of knee osteoarthritis: a mulitcenter, randomized, double-blind, sham-controlled trial.” Osteoarthritis and Cartilage (2017) p1-10.