In studies using iovera°
for knee pain, patients had:

  • Treatment process step 1 icon

    Up to 90 days of pain
    relief

  • Treatment process step 2 icon

    Improved range of motion after knee replacement surgery

  • Treatment process step 3 icon

    Reduced need for opioids 72 hours after surgery

  • Treatment process step 4 icon

    Immediate pain relief and less stiffness at 30 days

Beyond the knee, iovera° is also used to treat pain in the hip, shoulder, foot and ankle, spine, and more. It can also be used to treat pain related to rib fracture and mastectomy.

iovera° has been shown to provide immediate, long-lasting pain relief

See results in
OA knee pain See results in knee
replacement surgery

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Indication

iovera° applies freezing cold to peripheral nerve tissue to block and/or relieve pain for up to 90 days. It should not be used to treat central nervous system tissue.

Important safety information

The iovera° system should not be used in people with the following conditions:

  • Do not receive treatment with ioveraº if you experience hypersensitivity to cold or have open and/or infected wounds near the treatment site.
  • You may experience bruising, swelling, inflammation and/or redness, local pain and/or tenderness, and altered feeling at the site of application.
  • In treatment area(s), you may experience damage to the skin, skin darkening or lightening, and dimples in the skin.
  • You may experience a temporary loss of your ability to use your muscles normally outside of the treatment area.
  • Talk to your doctor before receiving treatment with ioveraº.
More +

Indication

iovera° applies freezing cold to peripheral nerve tissue to block and/or relieve pain for up to 90 days. It should not be used to treat central nervous system tissue.

Important Safety Information

Additional Information

Pacira Pharmaceuticals, Inc.

A subsidiary of Pacira Biosciences, Inc.

10410 Science Center Drive, Building A

San Diego, CA 92121 U.S.A

Legal Disclaimer

Zimmer Biomet acquired the iovera° business from Pacira BioSciences, Inc. on 31 Jul 2026, obtaining contractual agreement for the development, manufacture, and commercialization of iovera°.

During the transition period under the applicable Transition Services Agreement, Pacira remains the legal manufacturer for applicable iovera° products and retains the related regulatory responsibilities.

Zimmer Biomet acts as a contracted service provider, performing certain design, manufacturing, quality, and post-market activities under Pacira's quality system and oversight until the transition is complete.