The iovera° treatment is powered by the Focused Cold Therapy® delivery system, a convenient handheld device which harnesses the unique properties of cryotherapy to target peripheral nerves and immediately block pain. Highly pressurized liquid nitrous oxide (N2O) travels through the handpiece to the closed end needles of the Smart Tip, where it undergoes a phase change and becomes very cold. This phase change forms a precise cold zone in the tissue, causing a temporary nerve block.
Backed by a growing portfolio of over 75 patents and with over 3,000 patient treatments to date*, iovera° represents a widely growing option for physicians to manage their patients’ pain.
*As of Jan 2016
Sunderland, Nerves and Nerve Injuries, 1968, p.68.; Zhou, et al. Cryobiology. 2003 46:26–32.
Pre-clinical results from MYO-0448
Hsu and Stevenson. J. Neural Transm. 2014 121:15-20.
*Evans, et al. Br J Anaesth. 1981 53(11):1121-7.
Seeking to expand pain management treatment options beyond drugs (and their side effects) or existing nerve block therapies, the iovera° system uses the body’s natural response to cold for immediate pain relief. The platform iovera° system enables the use of Smart Tips to reach both deep and shallow peripheral nerves. Each Smart Tip is sterile and single patient use.
Listed below are examples of nerves that have been treated with the
iovera° system in clinical practice:
Data on file per myoscience report MYO-0867
|requested less opioids2
(12-week post period)
|reported less stiffness3
(6 & 12 weeks post)
|reported less knee pain3
(6 & 12 weeks post)
1 V. Dasa et al. Cryoneurolysis Nerve Block for Total Knee Arthroplasty. Myoscience Clinical Reports. 2016; 1(1):1-4.
2 iovera° patients requested 1933.75mg ave. morphine equivalents (MME) compared to 3751.25 mg for non-iovera° patients (p=0.0006).
3 Compared to a control group, iovera° patients had higher KOOS Pain Scores (difference of 11.2 & 13.4) and KOOS Symptom Scores (difference of 12 & 13.4) at 6 & 12 weeks post-surgery, respectively