The iovera° treatment is powered by the Focused Cold Therapy® delivery system, a convenient handheld device which harnesses the unique properties of cryotherapy to target peripheral nerves and immediately block pain. Highly pressurized liquid nitrous oxide (N2O) travels through the handpiece to the closed end needles of the Smart Tip, where it undergoes a phase change and becomes very cold. This phase change forms a precise cold zone in the tissue, causing a temporary nerve block.
Backed by a growing portfolio of over 88 patents and with over 12,000 patient treatments to date*, iovera° represents a widely growing option for physicians to manage their patients’ pain.
*As of March 2018
Sunderland, Nerves and Nerve Injuries, 1968, p.68.; Zhou, et al. Cryobiology. 2003 46:26–32.
Pre-clinical results from MYO-0448
Hsu and Stevenson. J. Neural Transm. 2014 121:15-20.
*Evans, et al. Br J Anaesth. 1981 53(11):1121-7.
Seeking to expand pain management treatment options beyond drugs (and their side effects) or existing nerve block therapies, the iovera° system uses the body’s natural response to cold for immediate pain relief. The platform iovera° system enables the use of Smart Tips to reach both deep and shallow peripheral nerves. Each Smart Tip is sterile and single patient use.
Listed below are examples of nerves that have been treated with the
iovera° system in clinical practice:
1 Reference: Radnovich, R. et al. “Cryoneurolysis to treat the pain and symptoms of knee osteoarthritis: a multicenter, randomized, double-blind, sham-controlled trial.” Osteoarthritis and Cartilage (2017) p1-10.
1 Reference: Dasa, V. et al. “Percutaneous freezing of sensory nerves prior to total knee arthroplasty.” The Knee (2016) p523-528.
1 Reference: Vinod Dasa, MD, Richard D. Berkowitz, MD, Antonia Chen, MD, Carlos Higuera, MD, Brian M. Ilfeld, MD, Martin Roche, MD, Juan C. Suarez, MD, Philip A. Stull, MD, Cryoneurolysis Prior to TKA for Post-Surgical Pain. Louisiana Orthopedics Association (LOA) Annual Meeting, Feb 2018.